Publications

2024

Lam, B., Retout, M., Clark, A.E., Garretson, A.F., Carlin, A.F., Jokerst, J.V. Silver Nanoparticle Sensor Array for the Detection of SARS-CoV-2. ACS Applied Nano Materials. 2024 Apr 15. DOI: https://doi.org/10.1021/acsanm.4c00654

Zhu, S., Pang, J., Nguyen, A., Tan, C., Tso, A., Huynh, T., Gu, Y., Gustafsson, A.B., Vaz, F.M., Evans, S.M., Fang, X. Temporal Effects of Safflower Oil Diet-Based Linoleic Acid Supplementation on Barth Syndrome Cardiomyopathy. Circulation. 2024 Mar 5;149(10):790-793. DOI: https://doi.org/10.1161/CIRCULATIONAHA.123.065414

Chung, Y.H., Zhao, Z., Jung, E., Omole, A.O., Wang, H., Sutorus, L., Steinmetz, N.F. Systemic Administration of Cowpea Mosaic Virus Demonstrates Broad Protection Against Metastatic Cancers. Adv Sci (Weinh). 2024 Mar 2:e2308237. DOI: https://doi.org/10.1002/advs.202308237

Ransom, L.S., Liu, C.S., Dunsmore, E., Palmer, C.R., Nicodemus, J., Ziomek, D., Williams, N., Chun, J. Human brain small extracellular vesicles contain selectively packaged, full-length mRNA. Cell Rep. 2024 Apr 4;43(4):114061. DOI: https://doi.org/10.1016/j.celrep.2024.114061

Zhou, Z., Ma, A., Moore, T.M., Wolf, D.M., Yang, N., Tran, P., Segawa, M., Strumwasser, A.R., Ren, W., Fu, K., Wanagat, J., van der Bliek, A.M., Crosbie-Watson, R., Liesa, M., Stiles, L., Acin-Perez, R., Mahata, S., Shirihai, O., Goodarzi, M.O., Handzlik, M., Metallo, C.M., Walker, D.W., Hevener, A.L. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Sci Adv. 2024 Apr 5;10(14):eadl0389. DOI: https://doi.org/10.1126/sciadv.adl0389

González-Gamboa I, Caparco AA, McCaskill J, Fuenlabrada-Velázquez P, Hays SS, Jin Z, Jokerst JV, Pokorski JK, Steinmetz NF. Inter-coat protein loading of active ingredients into Tobacco mild green mosaic virus through partial dissociation and reassembly of the virion. Sci Rep. 2024 Mar 26;14(1):7168. DOI: https://doi.org/10.1038/s41598-024-57200-0

Mishra, P., Sivakumar, A., Johnson, A., Pernaci, C., Warden, A.S., El-Hachem, L.R., Hansen, E., Badell-Grau, R.A., Khare, V., Ramirez, G., Gillette, S., Solis, A.B., Guo, P., Coufal, N., Cherqui, S. Gene editing improves endoplasmic reticulum-mitochondrial contacts and unfolded protein response in Friedreich's ataxia iPSC-derived neurons. Front Pharmacol. 2024 Feb 14;15:1323491. DOI: https://doi.org/10.3389/fphar.2024.1323491

Liang, W., Najor, R.H., Gustafsson, Å.B. Protocol to separate small and large extracellular vesicles from mouse and human cardiac tissues. STAR Protoc. 2024 Feb 21;5(1):102914. DOI: https://doi.org/10.1016/j.xpro.2024.102914

Profaci, C.P., Harvey, S.S., Bajc, K., Zhang, T.Z., Zhang, A.Z., Nemec, K.M., McKinsey, G.L., Longworth, A., McMullen, T.P., Arnold, T.D., Lawson, D.A., Bennett, F.C., Davalos, D., Daneman, R. Microglia are not required for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism. bioRxiv. 2024.02.20.580754. DOI: https://doi.org/10.1101/2024.02.20.580754

He, T., Wen, J., Wang, W., Hu, Z., Ling, C., Zhao, Z., Cheng, Y., Chang, Y.C., Xu, M., Jin, Z., Amer, L., Sasi, L., Fu, L., Steinmetz, N.F., Rana, T.M., Wu, P., Jokerst, J.V. Peptide-Driven Proton Sponge Nano-Assembly for Imaging and Triggering Lysosome-Regulated Immunogenic Cancer Cell Death. Adv Mater. 2024 Feb 19:e2307679. DOI: https://doi.org/10.1002/adma.202307679

Karan, S., Jung, E., Boone, C., Steinmetz, N.F. Synergistic combination therapy using cowpea mosaic virus intratumoral immunotherapy and Lag-3 checkpoint blockade. Cancer Immunol Immunother 73, 51 (2024). DOI: https://doi.org/10.1007/s00262-024-03636-2

Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T.E., Qian, J., Hung, C.W., Zhao, P., Jones, Y., Gao, H., Liddle, C., Yu, R.T., Downes, M., Evans, R.M., Rydén, M., Wabitsch, M., Wang, Z., Hakozaki, H., Schöneberg, J., Reilly, S.M., Huang, J., Saltiel, A.R. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nat Metab. 2024 Jan 29. DOI: https://doi.org/10.1038/s42255-024-00978-0

Wu, Z., Bayón, J.L., Kouznetsova, T.B., Ouchi, T., Barkovich, K.J., Hsu, S.K., Craig, S.L., Steinmetz, N.F. Virus-like Particles Armored by an Endoskeleton. Nano Lett. 2024 Jan 31. DOI: https://doi.org/10.1021/acs.nanolett.3c03806

Fujita, N., Girada, S., Vogler, G., Bodmer, R., Kiger, A.A. PI(4,5)P2 role in Transverse-tubule membrane formation and muscle function. bioRxiv. 2024 Jan 31:2024.01.31.578124. DOI: https://doi.org/10.1101/2024.01.31.578124

Chen, Z., Wang, S., Pottekat, A., Duffey, A., Jang, I., Chang, B.H., Cho, J., Finck, B.N., Davidson, N.O., Kaufman, R.J. Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion. Mol Metab. 2024 Jan 9;80:101874. DOI: https://doi.org/10.1016/j.molmet.2024.101874

Omole, A.O., Affonso de Oliveira, J.F., Sutorus, L., Steinmetz, N.F. Pharmacology of a Plant Virus Immunotherapy Candidate for Peritoneal Metastatic Ovarian Cancer. ACS Pharmacology & Translational Science Article ASAP. 2024 Jan 10. DOI: https://doi.org/10.1021/acsptsci.3c00285

2023

Barkovich, K.J., Zhao, Z., Steinmetz, N.F. iRGD-targeted Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Delivery. Small Sci. 2023 Aug;3(8):2300067. DOI: https://doi.org/10.1002/smsc.202300067

Shin, M.D., Jung, E., Moreno-Gonzalez, M.A., Ortega-Rivera, O.A., Steinmetz, N.F. Pluronic F127 "nanoarmor" for stabilization of Cowpea mosaic virus immunotherapy. Bioeng Transl Med. 2023 Jul 14;9(1):e10574. DOI: https://doi.org/10.1002/btm2.10574

Abasi, L.S., Elathram, N., Movva, M., Deep, A., Corbett, K.D., Debelouchina, G.T. Phosphorylation regulates tau's phase separation behavior and interactions with chromatin. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572911. DOI: https://doi.org/10.1101/2023.12.21.572911

Zhu, Y.P., Speir, M., Tan, Z., Lee, J.C., Nowell, C.J., Chen, A.A., Amatullah, H., Salinger, A.J., Huang, C.J., Wu, G., Peng, W., Askari, K., Griffis, E., Ghassemian, M., Santini, J., Gerlic, M., Kiosses, W.B., Catz, S.D., Hoffman, H.M., Greco, K.F., Weller, E., Thompson, P.R., Wong, L.P., Sadreyev, R., Jeffrey, K.L., Croker, B.A. NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils. Sci Adv. 2023 Dec 22;9(51):eadj1397. DOI: https://doi.org/10.1126/sciadv.adj1397

Goldberg, G., Coelho, L., Mo, G., Adang, L.A., Patne, M., Chen, Z., Garcia-Bassets, I., Mesci, P., Muotri, A.R. TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids. Mol Psychiatry. 2023 Dec 21. DOI: https://doi.org/10.1038/s41380-023-02348-w

Parra-Rivas, L.A., Madhivanan, K., Aulston, B.D., Wang, L., Prakashchand, D.D., Boyer, N.P., Saia-Cereda, V.M., Branes-Guerrero, K., Pizzo, D.P., Bagchi, P., Sundar, V.S., Tang, Y., Das, U., Scott, D.A., Rangamani, P., Ogawa, Y., Subhojit, Roy. Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function. Neuron. 2023 Dec 20;111(24):4006-4023.e10. DOI: https://doi.org/10.1016/j.neuron.2023.11.020

Kopp, E.L., Deussen, D.N., Cuomo, R., Lorenz, R., Roth, D.M., Mahata, S.K., Patel, H.H. Modeling and Phenotyping Acute and Chronic Type 2 Diabetes Mellitus In Vitro in Rodent Heart and Skeletal Muscle Cells. Cells. 2023 Dec 7;12(24):2786. DOI: https://doi.org/10.3390/cells12242786

Daboussi, L., Costaguta, G., Gullo, M., Jasinski, N., Pessino, V., O'Leary, B., Lettieri, K., Driscoll, S., Pfaff, S.L. Mitf is a Schwann cell sensor of axonal integrity that drives nerve repair. Cell Rep. 2023 Nov 28;42(11):113282. DOI: https://doi.org/10.1016/j.celrep.2023.113282

Lv, D., Zhong, C., Dixit, D., Yang, K., Wu, Q., Godugu, B., Prager, B.C., Zhao, G., Wang, X., Xie, Q., Bao, S., He, C., Heiland, D.H., Rosenfeld, M.G., Rich, J.N. EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma. Mol Cell. 2023 Nov 8:S1097-2765(23)00862-6. DOI: https://doi.org/10.1016/j.molcel.2023.10.025

Watanabe, R., Zyla, D., Parekh, D., Hong, C., Jones, Y., Schendel, S.L., Wan, W., Castillon, G., and Saphire, E.O. Intracellular Ebola Virus nucleocapsid assembly revealed by in situ cryo-electron tomography. bioRxiv. 2023 Dec 2. DOI: https://doi.org/10.1101/2023.12.01.569666

Piña, F., Yan, B., Hu, J., Niwa, M. Reticulons bind sphingolipids to activate the endoplasmic reticulum cell cycle checkpoint, the ER surveillance pathway. Cell Rep. 2023 Nov 17;42(12):113403. DOI: https://doi.org/10.1016/j.celrep.2023.113403

Cobián Güemes, A.G., Ghatbale, P., Blanc, A.N., Morgan, C.J., Garcia, A., Leonard, J., Huang, L., Kovalick, G., Proost, M., Chiu, M., Kuo, P., Oh, J., Karthikeyan, S., Knight, R., Pogliano, J., Schooley, R.T., Pride, D.T. Jumbo phages are active against extensively drug-resistant eyedrop-associated Pseudomonas aeruginosa infections. Antimicrob Agents Chemother. 2023 Nov 6:e0065423. DOI: https://doi.org/10.1128/aac.00654-23

López-Erauskin, J., Bravo-Hernandez, M., Presa, M., Baughn, M.W., Melamed, Z., Beccari, M.S., Agra de Almeida Quadros, A.R., Arnold-Garcia, O., Zuberi, A., Ling, K., Platoshyn, O., Niño-Jara, E., Ndayambaje, I.S., McAlonis-Downes, M., Cabrera, L., Artates, J.W., Ryan, J., Hermann, A., Ravits, J., Bennett, C.F., Jafar-Nejad, P., Rigo, F., Marsala, M., Lutz, C.M., Cleveland, D.W., Lagier-Tourenne, C. Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation. Nat Neurosci. 2023 Nov 23. DOI: https://doi.org/10.1038/s41593-023-01496-0

Lu, Y.S., Fan, R., Vugs, W., Biewenga, L., Zhou, Z., Vijayakumar, S., Merkx, M., and Sailor, M.J. Harnessing the Materials Chemistry of Mesoporous Silicon Nanoparticles to Prepare “Armor-Clad” Enzymes. Chemistry of Materials Article ASAP. 2023 Nov 24. DOI: https://doi.org/10.1021/acs.chemmater.3c02637

Amer, L., Retout, M., Jokerst, J.V. Activatable prodrug for controlled release of an antimicrobial peptide via the proteases overexpressed in Candida albicans and Porphyromonas gingivalis. BioRxiV. 2023 Nov 27:568833. DOI: https://doi.org/10.1101/2023.11.27.568833

Lu, Y.S., Fan, R., Vugs, W., Biewenga, L., Zhou, Z., Vijayakumar, S., Merkx, M., Sailor, M.J. Harnessing the Materials Chemistry of Mesoporous Silicon Nanoparticles to Prepare “Armor-Clad” Enzymes. Chemistry of Materials Article ASAP. 2023 Nov 24. DOI: https://doi.org/10.1021/acs.chemmater.3c02637

Venkatraman, K., Lee, C.T., Garcia, G.C., Mahapatra, A., Milshteyn, D., Perkins, G., Kim, K.Y., Pasolli, H.A., Phan, S., Lippincott-Schwartz, J., Ellisman, M.H., Rangamani, P., Budin, I. Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome. EMBO J. 2023 Nov 7:e114054. DOI: https://doi.org/10.15252/embj.2023114054

Anandachar, M.S., Roy, S., Sinha, S., Boadi, A., Katkar, G.D., Ghosh, P. Diverse gut pathogens exploit the host engulfment pathway via a conserved mechanism. J Biol Chem. 2023 Oct 25:105390. DOI: https://doi.org/10.1016/j.jbc.2023.105390

Kaneko, K., Liang, Y., Liu, Q., Zhang, S., Scheiter, A., Song, D., Feng, G.S. Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit. Elife. 2023 Oct 17;12:RP86824. DOI: https://doi.org/10.7554/eLife.86824.3

Krishnan, N., Jiang, Y., Zhou, J., Mohapatra, A., Peng, F.X., Duan, Y., Holay, M., Chekuri, S., Guo, Z., Gao, W., Fang, R.H., Zhang, L. A modular approach to enhancing cell membrane-coated nanoparticle functionality using genetic engineering. Nat Nanotechnol. 2023 Oct 30. DOI: https://doi.org/10.1038/s41565-023-01533-w

Han, K., Zhang, Z., Tezcan, F.A. Spatially Patterned, Porous Protein Crystals as Multifunctional Materials. J Am Chem Soc. 2023 Sep 13;145(36):19932-19944. DOI: https://doi.org/10.1021/jacs.3c06348

Kopp, E.L., Deussen, D.N., Cuomo, R., Lorenz, R., Roth, D.M., Mahata, S.K., and Patel, H.H. (2023). Diabetes in a Dish: Modeling and Phenotyping Acute and Chronic Type 2 Diabetes Mellitus In Vitro in Rodent Heart and Skeletal Muscle Cells. Preprints.org. 2023 Oct 9. DOI: https://doi.org/10.20944/preprints202310.0319.v1

Yu, C., Nelson, S.L., Meisl, G., Ghirlando, R., and Deshmukh, L. (2023). Phase Separation and Fibrillization of Human Annexin A7 Are Mediated by Its Proline-Rich Domain. Biochemistry. 2023 Oct 3. DOI: 10.1021/acs.biochem.3c00349

Ruan, X., Cao, M., Yan, W., Jones, Y.Z., Gustafsson, Å.B., Patel, H.H., Schenk, S., and Wang, S.E. (2023). Cancer-cell-secreted extracellular vesicles target p53 to impair mitochondrial function in muscle. EMBO Rep. 2023 Sep 6;24(9):e56464. DOI: 10.15252/embr.202256464

Barkovich, K.J., Wu, Z., Zhao, Z., Simms, A., Chang, E.Y., and Steinmetz, N.F. (2023). Physalis Mottle Virus-Like Nanocarriers with Expanded Internal Loading Capacity. Bioconjug Chem. 2023 Sep 20;34(9):1585-1595. DOI: 10.1021/acs.bioconjchem.3c00269

Jung, E., Chung, Y.H., and Steinmetz, N.F. (2023). TLR Agonists Delivered by Plant Virus and Bacteriophage Nanoparticles for Cancer Immunotherapy. Bioconjug Chem. 2023 Sep 20;34(9):1596-1605. DOI: 10.1021/acs.bioconjchem.3c00271

Sullivan, H.L., Liang, Y., Worthington, K., Luo, C., Gianneschi, N.C., and Christman, K.L. (2023). Enzyme-Responsive Nanoparticles for the Targeted Delivery of an MMP Inhibitor to Acute Myocardial Infarction. Biomacromolecules. DOI: 10.1021/acs.biomac.3c00421

Creyer, M.N., Retout, M., Jin, Z., Yim, W., and Jokerst, J.V. (2023). Ligation of Gold Nanoparticles with Self-Assembling, Coiled-Coil Peptides. J Phys Chem B. 2023 Sep 21;127(37):8009-8018. DOI: 10.1021/acs.jpcb.3c02099

Retout, M., Amer, L., Yim, W., Creyer, M.N., Lam, B., Trujillo, D.F., Potempa, J., O'Donoghue, A.J., Chen, C., Jokerst, J.V., et al. (2023). A Protease-Responsive Polymer/Peptide Conjugate and Reversible Assembly of Silver Clusters for the Detection of Porphyromonas gingivalis Enzymatic Activity. ACS Nano. 2023 Sep 12;17(17):17308-17319. DOI: 10.1021/acsnano.3c05268

Cheng, Y., Clark, A.E., Yim, W., Borum, R.M., Chang, Y.C., Jin, Z., He, T., Carlin, A.F., Jokerst, J.V., et al. (2023). Protease-Responsive Potential-Tunable AIEgens for Cell Selective Imaging of TMPRSS2 and Accurate Inhibitor Screening. Anal Chem. 2023 Feb 21;95(7):3789-3798. DOI: 10.1021/acs.analchem.2c04988

Yeung, J., Jin, Z., Ling, C., Retout, M., Barbosa da Silva, E., Damani, M., Chang, Y.C., Yim, W., O'Donoghue, A.J., Jokerst, J.V., et al. (2023). An approach to zwitterionic peptide design for colorimetric detection of the Southampton norovirus SV3CP protease. Analyst. 2023 Sep 11;148(18):4504-4512. DOI: 10.1039/d3an00873h

Ai, X., Wang, D., Noh, I., Duan, Y., Zhou, Z., Mukundan, N., Fang, R.H., Gao, W., Zhang, L., et al. (2023). Glycan-modified cellular nanosponges for enhanced neutralization of botulinum toxin. Biomaterials. 2023 Sep 16;302:122330. DOI: 10.1016/j.biomaterials.2023.122330

Ling, C., Jin, Z., Yeung, J., da Silva, E.B., Chang, Y.C., He, T., Yim, W., O'Donoghue, A.J., Jokerst, J.V., et al. (2023). Valence-driven colorimetric detection of norovirus protease via peptide-AuNP interactions. Chem Commun (Camb). DOI: 10.1039/d3cc04142e

Sako, Y., Sato-Kaneko, F., Shukla, N.M., Yao, S., Belsuzarri, M.M., Chan, M., Saito, T., Lao, F.S., Kong, H., Puffer, M., et al. (2023). Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx. ACS Chem Biol 18, 982-993. DOI: 10.1021/acschembio.3c00134

Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T., Qian, J., Hung, C.W., Zhao, P., Jones, Y., Gao, H., et al. (2023). Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes. Res Sq. DOI: 10.21203/rs.3.rs-2923510/v1.

Yim, W., Retout, M., Chen, A.A., Ling, C., Amer, L., Jin, Z., Chang, Y.C., Chavez, S., Barrios, K., Lam, B., et al. (2023). Goldilocks Energy Minimum: Peptide-Based Reversible Aggregation and Biosensing. ACS Appl Mater Interfaces. DOI: 10.1021/acsami.3c09627

Zhou, Z., Kai, M., Wang, S., Wang, D., Peng, Y., Yu, Y., Gao, W., and Zhang, L. (2023). Emerging nanoparticle designs against bacterial infections. Wiley Interdiscip Rev Nanomed Nanobiotechnol 15, e1881. DOI: 10.1002/wnan.1881

Duan, Y., Zhang, E., Fang, R.H., Gao, W., and Zhang, L. (2023). Capsulated Cellular Nanosponges for the Treatment of Experimental Inflammatory Bowel Disease. ACS Nano 17, 15893-15904. DOI: 10.1021/acsnano.3c03959

Duan, Y., Zhou, J., Zhou, Z., Zhang, E., Yu, Y., Krishnan, N., Silva-Ayala, D., Fang, R.H., Griffiths, A., Gao, W., and Zhang, L. (2023). Extending the In Vivo Residence Time of Macrophage Membrane-Coated Nanoparticles through Genetic Modification. Small, e2305551. DOI: 10.1002/smll.202305551

Guo, Z., Noh, I., Zhu, A.T., Yu, Y., Gao, W., Fang, R.H., and Zhang, L. (2023). Cancer Cell Membrane Nanodiscs for Antitumor Vaccination. Nano Lett. DOI: 10.1021/acs.nanolett.3c01775

2022

Retout, M., Gosselin, B., Jokerst, J.V., Jabin, I., Bruylants, G., et al. (2022). A fluoride-induced aggregation test to quickly assess the efficiency of ligand exchange procedures from citrate capped AuNPs. Colloids Surf A Physicochem Eng Asp. 2023 Mar 5;660:130801. DOI: 10.1016/j.colsurfa.2022.130801

Lu, S., Hu, J., Arogundade, O.A., Goginashvili, A., Vazquez-Sanchez, S., Diedrich, J.K., Gu, J., Blum, J., Oung, S., Ye, Q., et al. (2022). Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition. Nature Cell Biology. DOI: 10.1038/s41556-022-00988-8

Maity, S., Chakraborty, A., Mahata, S.K., Roy, S., Das, A.K., and Sen, M. (2022). Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis. Frontiers in Immunology 13. DOI: 10.3389/fimmu.2022.818266

Mantri, Y., Sit, I., Zhou, J., Grassian, V.H., and Jokerst, J.V. (2022). Photoacoustic Enhancement of Ferricyanide-Treated Silver Chalcogenide-Coated Gold Nanorods. J Phys Chem C Nanomater Interfaces 126, 7605-7614. DOI: 10.1021/acs.jpcc.2c01727

Mantuano, E., Azmoon, P., Banki, M.A., Sigurdson, C.J., Campana, W.M., and Gonias, S.L. (2022). A Soluble PrPC Derivative and Membrane-Anchored PrPC in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA-R/LRP1 Receptor Complex. The Journal of Immunology 208. DOI: 10.4049/jimmunol.2100412

Monroy-Borrego, A.G., and Steinmetz, N.F. (2022). Three methods for inoculation of viral vectors into plants. Front Plant Sci 13, 963756. DOI: 10.3389/fpls.2022.963756

Montaño, E.T., Nideffer, J.F., Brumage, L., Erb, M., Busch, J., Fernandez, L., Derman, A.I., Davis, J.P., Estrada, E., Fu, S., et al. (2022). Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals. PLoS ONE 17. DOI: 10.1371/journal.pone.0262354

Muntjewerff, E.M., Christoffersson, G., Mahata, S.K., and van den Bogaart, G. (2022). Putative regulation of macrophage-mediated inflammation by catestatin. Trends in Immunology. DOI: 10.1016/j.it.2021.11.002

Nkanga, C.I., Ortega-Rivera, O.A., Shin, M.D., Moreno-Gonzalez, M.A., and Steinmetz, N.F. (2022). Injectable Slow-Release Hydrogel Formulation of a Plant Virus-Based COVID-19 Vaccine Candidate. Biomacromolecules 23. 10.1021/acs.biomac.2c00112. DOI: 10.1021/acs.biomac.2c00112

Noh, I., Guo, Z., Zhou, J., Gao, W., Fang, R.H., and Zhang, L. (2022). Cellular Nanodiscs Made from Bacterial Outer Membrane as a Platform for Antibacterial Vaccination. ACS Nano. DOI: 10.1021/acsnano.2c08360

Ojeda-Juárez, D., Lawrence, J.A., Soldau, K., Pizzo, D.P., Wheeler, E., Aguilar-Calvo, P., Khuu, H., Chen, J., Malik, A., Funk, G., et al. (2022). Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus. Neurobiology of Disease 172. DOI: 10.1016/j.nbd.2022.105834

Parchure, A., Tian, M., Stalder, D., Boyer, C.K., Bearrows, S.C., Rohli, K.E., Zhang, J., Rivera-Molina, F., Ramazanov, B.R., Mahata, S.K., et al. (2022). Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules. Journal of Cell Biology 221. DOI: 10.1083/jcb.202206132

Park, D.J., Duggan, E., Ho, K., Dorschner, R.A., Dobke, M., Nolan, J.P., and Eliceiri, B.P. (2022). Serpin-loaded extracellular vesicles promote tissue repair in a mouse model of impaired wound healing. J Nanobiotechnology 20, 474. DOI: 10.1186/s12951-022-01656-7

Park, D.J., Duggan, E., Ho, K., Dorschner, R.A., Dobke, M., Nolan, J.P., and Eliceiri, B.P. (2022). Serpin-loaded extracellular vesicles promote tissue repair in a mouse model of impaired wound healing. Journal of Nanobiotechnology 20. DOI: 10.1186/s12951-022-01656-7

Powers, J.D., Kirkland, N.J., Liu, C., Razu, S.S., Fang, X., Engler, A.J., Chen, J., and McCulloch, A.D. (2022). Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy. International Journal of Molecular Sciences 23. DOI: 10.3390/ijms23020871

Ray, S., Wirth, D.M., Ortega-Rivera, O.A., Steinmetz, N.F., and Pokorski, J.K. (2022). Dissolving Microneedle Delivery of a Prophylactic HPV Vaccine. Biomacromolecules 23. DOI: 10.1021/acs.biomac.1c01345

Sadri, M., Hirosawa, N., Le, J., Romero, H., Martellucci, S., Kwon, H.J., Pizzo, D., Ohtori, S., Gonias, S.L., and Campana, W.M. (2022). Tumor necrosis factor receptor-1 is selectively sequestered into Schwann cell extracellular vesicles where it functions as a TNFα decoy. GLIA 70. DOI: 10.1002/glia.24098

Sit, I., Quirk, E., Hettiarachchi, E., and Grassian, V.H. (2022). Differential Surface Interactions and Surface Templating of Nucleotides (dGMP, dCMP, dAMP, and dTMP) on Oxide Particle Surfaces. Langmuir 38. DOI: 10.1021/acs.langmuir.2c01604

Tran, T.D., Ali, M.A., Lee, D., Félix, M.A., and Luallen, R.J. (2022). Bacterial filamentation as a mechanism for cell-to-cell spread within an animal host. Nature Communications 13. DOI: 10.1038/s41467-022-28297-6

Waggoner, L.E., Kang, J., Zuidema, J.M., Vijayakumar, S., Hurtado, A.A., Sailor, M.J., and Kwon, E.J. (2022). Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury. Bioconjugate Chemistry 33. DOI: 10.1021/acs.bioconjchem.2c00305

Wu, Z., Zhou, J., Nkanga, C.I., Jin, Z., He, T., Borum, R.M., Yim, W., Zhou, J., Cheng, Y., Xu, M., et al. (2022). One-Step Supramolecular Multifunctional Coating on Plant Virus Nanoparticles for Bioimaging and Therapeutic Applications. ACS Applied Materials and Interfaces 14. DOI: 10.1021/acsami.1c22690

Cao, M., Isaac, R., Yan, W., Ruan, X., Jiang, L., Wan, Y., Wang, J., Wang, E., Caron, C., Neben, S., et al. (2022). Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nature Cell Biology 24. DOI: 10.1038/s41556-022-00919-7

Yim, W., Borum, R.M., Zhou, J., Mantri, Y., Wu, Z., Zhou, J., Jin, Z., Creyer, M., and Jokerst, J.V. (2022). Ultrasmall gold nanorod-polydopamine hybrids for enhanced photoacoustic imaging and photothermal therapy in second near-infrared window. Nanotheranostics 6. DOI: 10.7150/ntno.63634

Yim, W., Takemura, K., Zhou, J., Zhou, J., Jin, Z., Borum, R.M., Xu, M., Cheng, Y., He, T., Penny, W., et al. (2022). Enhanced Photoacoustic Detection of Heparin in Whole Blood via Melanin Nanocapsules Carrying Molecular Agents. ACS Nano 16. DOI: 10.1021/acsnano.1c08178

Zhou, J., Krishnan, N., Guo, Z., Ventura, C.J., Holay, M., Zhang, Q., Wei, X., Gao, W., Fang, R.H., and Zhang, L. (2022). Nanotoxoid vaccination protects against opportunistic bacterial infections arising from immunodeficiency. Science Advances 8. DOI: 10.1126/sciadv.abq5492

Zhou, J., Miyamoto, Y., Ihara, S., Kroll, A.V., Nieskens, N., Tran, V.N., Hanson, E.M., Fang, R.H., Zhang, L., and Eckmann, L. (2022). Codelivery of Antigens and Adjuvant in Polymeric Nanoparticles Coated With Native Parasite Membranes Induces Protective Mucosal Immunity Against Giardia lamblia. Journal of Infectious Diseases 226. DOI: 10.1093/infdis/jiac074

Zhu, B., Liu, Y., Hwang, S., Archuleta, K., Huang, H., Campos, A., Murad, R., Piña-Crespo, J., Xu, H., and Huang, T.Y. (2022). Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Molecular Neurodegeneration 17. DOI: 10.1186/s13024-022-00562-8

Chan, S.K., and Steinmetz, N.F. (2022). Isolation of Tobacco Mosaic Virus-Binding Peptides for Biotechnology Applications. ChemBioChem 23. DOI: 10.1002/cbic.202200040

Cobo, I., Tanaka, T.N., Chandra Mangalhara, K., Lana, A., Yeang, C., Han, C., Schlachetzki, J., Challcombe, J., Fixsen, B.R., Sakai, M., et al. (2022). DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity 55. DOI: 10.1016/j.immuni.2022.06.022

Gao, H., Luo, Z., Ji, Y., Tang, K., Jin, Z., Ly, C., Sears, D.D., Mahata, S., and Ying, W. (2022). Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice. Nature Communications 13. DOI: 10.1038/s41467-022-28239-2

Gonias, S.L., Banki, M.A., Azmoon, P., Romero, H.K., Sigurdson, C.J., Mantuano, E., and Campana, W.M. (2022). Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor-LRP1 receptor system. Journal of Biological Chemistry 298. DOI: 10.1016/j.jbc.2022.101642

González-Dávila, P., Schwalbe, M., Danewalia, A., Wardenaar, R., Dalile, B., Verbeke, K., Mahata, S.K., and El Aidy, S. (2022). Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts. Gut Microbes 14. DOI: 10.1080/19490976.2022.2081476

Bandyopadhyay, G., Tang, K., Webster, N.J.G., van den Bogaart, G., and Mahata, S.K. (2022). Catestatin induces glycogenesis by stimulating the phosphoinositide 3-kinase-AKT pathway. Acta Physiologica 235. DOI: 10.1111/apha.13775

Kim, J.Y., Wang, L., Sladky, V.C., Oh, T.G., Liu, J., Trinh, K., Eichin, F., Downes, M., Hosseini, M., Jacotot, E.D., et al. (2022). PIDDosome-SCAP Crosstalk Controls Diet Dependent Transition from Simple Steatosis to Steatohepatitis. SSRN Electronic Journal. DOI: 10.2139/ssrn.4029141

Koellhoffer, E.C., Mao, C., Beiss, V., Wang, L., Fiering, S.N., Boone, C.E., and Steinmetz, N.F. (2022). Inactivated Cowpea Mosaic Virus in Combination with OX40 Agonist Primes Potent Antitumor Immunity in a Bilateral Melanoma Mouse Model. Molecular Pharmaceutics 19. DOI: 10.1021/acs.molpharmaceut.1c00681

Bernareggi, D., Xie, Q., Prager, B.C., Yun, J., Cruz, L.S., Pham, T.V., Kim, W., Lee, X., Coffey, M., Zalfa, C., et al. (2022). CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity. Nature Communications 13. DOI: 10.1038/s41467-022-29469-0

Lewandowski, D., Sander, C.L., Tworak, A., Gao, F., Xu, Q., and Skowronska-Krawczyk, D. (2022). Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life. Progress in Retinal and Eye Research. DOI: 10.1016/j.preteyeres.2021.101037

Liu, D., Mari, M., Li, X., Reggiori, F., Ferro-Novick, S., and Novick, P. (2022). ER-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits. Proceedings of the National Academy of Sciences of the United States of America 119. DOI: 10.1073/pnas.2117554119

Liu, M.A., Shahabi, S., Jati, S., Tang, K., Gao, H., Jin, Z., Miller, W., Meunier, F.A., Ying, W., Bogaart, G.v.d., et al. (2022). Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes. Frontiers in Endocrinology 13. DOI: 10.3389/fendo.2022.1037465

Long, T., Abbasi, N., Hernandez, J.E., Li, Y., Sayed, I.M., Ma, S., Iemolo, A., Yee, B.A., Yeo, G.W., Telese, F., et al. (2022). RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine. Gut 71. DOI: 10.1136/gutjnl-2021-324984

2021

Ai, X., Wang, S., Duan, Y., Zhang, Q., Chen, M.S., Gao, W., and Zhang, L. (2021). Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles. Biochemistry. DOI: 10.1021/acs.biochem.0c00343

Luo, Z., Ji, Y., Gao, H., Gomes Dos Reis, F.C., Bandyopadhyay, G., Jin, Z., Ly, C., Chang, Y.j., Zhang, D., Kumar, D., and Ying, W. (2021). CRIg+ Macrophages Prevent Gut Microbial DNA–Containing Extracellular Vesicle–Induced Tissue Inflammation and Insulin Resistance. Gastroenterology 160. DOI: 10.1053/j.gastro.2020.10.042

Machado, H., Seif, Y., Sakoulas, G., Olson, C.A., Hefner, Y., Anand, A., Jones, Y.Z., Szubin, R., Palsson, B.O., Nizet, V., and Feist, A.M. (2021). Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus. Communications biology 4. DOI: 10.1038/s42003-021-02339-z

Bhattacharya, A., Cho, C.J., Brea, R.J., and Devaraj, N.K. (2021). Expression of Fatty Acyl-CoA Ligase Drives One-Pot de Novo Synthesis of Membrane-Bound Vesicles in a Cell-Free Transcription-Translation System. Journal of the American Chemical Society 143. DOI: 10.1021/jacs.1c05394

Muntjewerff, E.M., Tang, K., Lutter, L., Christoffersson, G., Nicolasen, M.J.T., Gao, H., Katkar, G.D., Das, S., ter Beest, M., Ying, W., et al. (2021). Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides. Acta Physiologica 232. DOI: 10.1111/apha.13655

Nandi, S.S., Katsurada, K., Mahata, S.K., and Patel, K.P. (2021). Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR- 18a-5p-HIF-1α Axis. Frontiers in Physiology 12. DOI: 10.3389/fphys.2021.718982

Nkanga, C.I., Chung, Y.H., Shukla, S., Zhou, J., Jokerst, J.V., and Steinmetz, N.F. (2021). The in vivo fate of tobacco mosaic virus nanoparticle theranostic agents modified by the addition of a polydopamine coat. Biomaterials Science 9. DOI: 10.1039/d1bm01113h

Ortega-Rivera, O.A., Pokorski, J.K., and Steinmetz, N.F. (2021). A Single-Dose, Implant-Based, Trivalent Virus-like Particle Vaccine against “Cholesterol Checkpoint” Proteins. Advanced Therapeutics 4. DOI: 10.1002/adtp.202100014

Ortega-Rivera, O.A., Shin, M.D., Chen, A., Beiss, V., Moreno-Gonzalez, M.A., Lopez-Ramirez, M.A., Reynoso, M., Wang, H., Hurst, B.L., Wang, J., et al. (2021). Trivalent Subunit Vaccine Candidates for COVID-19 and Their Delivery Devices. Journal of the American Chemical Society 143. DOI: 10.1021/jacs.1c06600

Ortega-Rivera, O.A., Shukla, S., Shin, M.D., Chen, A., Beiss, V., Moreno-Gonzalez, M.A., Zheng, Y., Clark, A.E., Carlin, A.F., Pokorski, J.K., and Steinmetz, N.F. (2021). Cowpea Mosaic Virus Nanoparticle Vaccine Candidates Displaying Peptide Epitopes Can Neutralize the Severe Acute Respiratory Syndrome Coronavirus. ACS Infectious Diseases 7. DOI: 10.1021/acsinfecdis.1c00410

Park, J.H., Jiang, Y., Zhou, J., Gong, H., Mohapatra, A., Heo, J., Gao, W., Fang, R.H., and Zhang, L. (2021). Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs. Science Advances 7. DOI: 10.1126/sciadv.abf7820

Riffelmacher, T., Giles, D.A., Zahner, S., Dicker, M., Andreyev, A.Y., McArdle, S., Perez-Jeldres, T., van der Gracht, E., Murray, M.P., Hartmann, N., et al. (2021). Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils. Mucosal Immunology 14. DOI: 10.1038/s41385-021-00378-7

Shin, M.D., Hochberg, J.D., Pokorski, J.K., and Steinmetz, N.F. (2021). Bioconjugation of Active Ingredients to Plant Viral Nanoparticles Is Enhanced by Preincubation with a Pluronic F127 Polymer Scaffold. ACS Applied Materials and Interfaces 13. DOI: 10.1021/acsami.1c13183

Shpigelman, J., Lao, F.S., Yao, S., Li, C., Saito, T., Sato-Kaneko, F., Nolan, J.P., Shukla, N.M., Pu, M., Messer, K., et al. (2021). Generation and Application of a Reporter Cell Line for the Quantitative Screen of Extracellular Vesicle Release. Frontiers in Pharmacology 12. DOI: 10.3389/fphar.2021.668609

Shukla, S., Marks, I., Church, D., Chan, S.K., Pokorski, J.K., and Steinmetz, N.F. (2021). Tobacco mosaic virus for the targeted delivery of drugs to cells expressing prostate-specific membrane antigen. RSC Advances 11. DOI: 10.1039/d1ra03166j

Somkuwar, S.S., Villalpando, E.G., Quach, L.W., Head, B.P., McKenna, B.S., Scadeng, M., and Mandyam, C.D. (2021). Abstinence from ethanol dependence produces concomitant cortical gray matter abnormalities, microstructural deficits and cognitive dysfunction. European Neuropsychopharmacology 42. DOI: 10.1016/j.euroneuro.2020.11.010

Campbell, G.R., Zhuang, J., Zhang, G., Landa, I., Kubiatowicz, L.J., Dehaini, D., Fang, R.H., Zhang, L., and Spector, S.A. (2021). CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells. Theranostics 11. DOI: 10.7150/thno.59728

Campeau, A., Uchiyama, S., Sanchez, C., Sauceda, C., Nizet, V., and Gonzalez, D.J. (2021). The S Protein of Group B Streptococcus Is a Critical Virulence Determinant That Impacts the Cell Surface Virulome. Frontiers in Microbiology 12. DOI: 10.3389/fmicb.2021.729308

Wang, S., Leem, J.S., Podvin, S., Hook, V., Kleschevnikov, N., Savchenko, P., Dhanani, M., Zhou, K., Kelly, I.C., Zhang, T., et al. (2021). Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD. Molecular Therapy - Methods & Clinical Development 21. DOI: 10.1016/j.omtm.2021.03.021

Yim, W., Zhou, J., Mantri, Y., Creyer, M.N., Moore, C.A., and Jokerst, J.V. (2021). Gold Nanorod-Melanin Hybrids for Enhanced and Prolonged Photoacoustic Imaging in the Near-Infrared-II Window. ACS Applied Materials and Interfaces 13. DOI: 10.1021/acsami.1c00993

Ying, W., Gao, H., Dos Reis, F.C.G., Bandyopadhyay, G., Ofrecio, J.M., Luo, Z., Ji, Y., Jin, Z., Ly, C., and Olefsky, J.M. (2021). MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice. Cell Metabolism 33. DOI: 10.1016/j.cmet.2020.12.019

Ying, W., Tang, K., Avolio, E., Schilling, J.M., Pasqua, T., Liu, M.A., Cheng, H., Gao, H., Zhang, J., Mahata, S., et al. (2021). Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension 77. DOI: 10.1161/HYPERTENSIONAHA.120.16809

Yong, J., Parekh, V.S., Reilly, S.M., Nayak, J., Chen, Z., Lebeaupin, C., Jang, I., Zhang, J., Prakash, T.P., Sun, H., et al. (2021). Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice. Science Translational Medicine 13. DOI: 10.1126/scitranslmed.aba9796

Yu, H., Lu, S., Gasior, K., Singh, D., Vazquez-Sanchez, S., Tapia, O., Toprani, D., Beccari, M.S., Yates, J.R., Da Cruz, S., et al. (2021). HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science 371. DOI: 10.1126/science.abb4309

Zemljic-Harpf, A.E., See Hoe, L.E., Schilling, J.M., Zuniga-Hertz, J.P., Nguyen, A., Vaishnav, Y.J., Belza, G.J., Budiono, B.P., Patel, P.M., Head, B.P., et al. (2021). Morphine induces physiological, structural, and molecular benefits in the diabetic myocardium. FASEB Journal 35. DOI: 10.1096/fj.201903233R

Zhao, M., Quintana, A., Zhang, C., Andreyev, A.Y., Kiosses, W., Kuwana, T., Murphy, A., Hogan, P.G., and Kronenberg, M. (2021). Calcium signals regulate the functional differentiation of thymic iNKT cells. The EMBO Journal 40. DOI: 10.15252/embj.2021107901

Zhou, J., Creyer, M.N., Chen, A., Yim, W., Lafleur, R.P.M., He, T., Lin, Z., Xu, M., Abbasi, P., Wu, J., et al. (2021). Stereoselective Growth of Small Molecule Patches on Nanoparticles. Journal of the American Chemical Society 143. DOI: 10.1021/jacs.1c04272

Zhou, J., Penna, M., Lin, Z., Han, Y., Lafleur, R.P.M., Qu, Y., Richardson, J.J., Yarovsky, I., Jokerst, J.V., and Caruso, F. (2021). Robust and Versatile Coatings Engineered via Simultaneous Covalent and Noncovalent Interactions. Angewandte Chemie - International Edition 60. DOI: 10.1002/anie.202106316

Chan, S.K., Du, P., Ignacio, C., Mehta, S., Newton, I.G., and Steinmetz, N.F. (2021). Biomimetic Virus-Like Particles as Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostic Tools. ACS Nano 15. DOI: 10.1021/acsnano.0c08430

Zhu, S., Chen, Z., Zhu, M., Shen, Y., Leon, L.J., Chi, L., Spinozzi, S., Tan, C., Gu, Y., Nguyen, A., et al. (2021). Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy. Circulation: Heart Failure 14. DOI: 10.1161/CIRCHEARTFAILURE.121.008289

Chan, S.K., Du, P., Ignacio, C., Mehta, S., Newton, I.G., and Steinmetz, N.F. (2021). Virus-Like Particles as Positive Controls for COVID-19 RT-LAMP Diagnostic Assays. Biomacromolecules 22. DOI: 10.1021/acs.biomac.0c01727

Chan, S.K., and Steinmetz, N.F. (2021). Isolation of Cowpea Mosaic Virus-Binding Peptides. Biomacromolecules 22. DOI: 10.1021/acs.biomac.1c00712

Chang, Y.J., Tuz-Zahra, F., Godbole, S., Avitia, Y., Bellettiere, J., Rock, C.L., Jankowska, M.M., Allison, M.A., Dunstan, D.W., Rana, B., et al. (2021). Endothelial-derived cardiovascular disease-related microRNAs elevated with prolonged sitting pattern among postmenopausal women. Scientific Reports 11. DOI: 10.1038/s41598-021-90154-1

Chariou, P.L., Beiss, V., Ma, Y., and Steinmetz, N.F. (2021). In situ vaccine application of inactivated CPMV nanoparticles for cancer immunotherapy. Materials Advances 2. DOI: 10.1039/d0ma00752h

Dorrier, C.E., Aran, D., Haenelt, E.A., Sheehy, R.N., Hoi, K.K., Pintarić, L., Chen, Y., Lizama, C.O., Cautivo, K.M., Weiner, G.A., et al. (2021). CNS fibroblasts form a fibrotic scar in response to immune cell infiltration. Nature Neuroscience 24. DOI: 10.1038/s41593-020-00770-9

Elias, R.D., Ramaraju, B., and Deshmukh, L. (2021). Mechanistic roles of tyrosine phosphorylation in reversible amyloids, autoinhibition, and endosomal membrane association of ALIX. Journal of Biological Chemistry 297. DOI: 10.1016/j.jbc.2021.101328

Bahmani, B., Gong, H., Luk, B.T., Haushalter, K.J., DeTeresa, E., Previti, M., Zhou, J., Gao, W., Bui, J.D., Zhang, L., et al. (2021). Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors. Nature Communications 12. DOI: 10.1038/s41467-021-22311-z

Gautam, A., Beiss, V., Wang, C., Wang, L., and Steinmetz, N.F. (2021). Plant viral nanoparticle conjugated with anti-pd-1 peptide for ovarian cancer immunotherapy. International Journal of Molecular Sciences 22. DOI: 10.3390/ijms22189733

Guan, J., Guo, H., Tang, T., Wang, Y., Wei, Y., Seth, P., Li, Y., Dehm, S.M., Ruoslahti, E., and Pang, H.B. (2021). iRGD-Liposomes Enhance Tumor Delivery and Therapeutic Efficacy of Antisense Oligonucleotide Drugs against Primary Prostate Cancer and Bone Metastasis. Advanced Functional Materials 31. DOI: 10.1002/adfm.202100478

Guzman, M., Lundborg, L.R., Yeasmin, S., Tyler, C.J., Zgajnar, N.R., Taupin, V., Dobaczewska, K., Mikulski, Z., Bamias, G., and Rivera-Nieves, J. (2021). An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium. Mucosal Immunology 14. DOI: 10.1038/s41385-021-00439-x

Hu, H., and Steinmetz, N.F. (2021). Development of a virus-like particle-based Anti-HER2 breast cancer vaccine. Cancers 13. DOI: 10.3390/cancers13122909

Ji, Y., Luo, Z., Gao, H., Dos Reis, F.C.G., Bandyopadhyay, G., Jin, Z., Manda, K.A., Isaac, R., Yang, M., Fu, W., et al. (2021). Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nature Metabolism 3. DOI: 10.1038/s42255-021-00444-1

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Kim, B., Yang, Q., Chan, L.W., Bhatia, S.N., Ruoslahti, E., and Sailor, M.J. (2021). Fusogenic porous silicon nanoparticles as a broad-spectrum immunotherapy against bacterial infections. Nanoscale Horizons 6. DOI: 10.1039/d0nh00624f

Li, Y., Nourbakhsh, N., Pham, H., Tham, R., Zuckerman, J.E., and Singh, P. (2021). Erratum: Evolution of altered tubular metabolism and mitochondrial function in sepsis-associated acute kidney injury. American Journal of Physiology - Renal Physiology. DOI: 10.1152/ajprenal.00390.2019

Liang, Y., Lyon, R.C., Pellman, J., Bradford, W.H., Lange, S., Bogomolovas, J., Dalton, N.D., Gu, Y., Bobar, M., Lee, M.-H., et al. (2021). Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Journal of Clinical Investigation 131. DOI: 10.1172/JCI137689

2020

Manso, A.M., Hashem, S.I., Nelson, B.C., Gault, E., Soto-Hermida, A., Villarruel, E., Brambatti, M., Bogomolovas, J., Bushway, P.J., Chen, C., et al. (2020). Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease. Science Translational Medicine 12. DOI: 10.1126/scitranslmed.aax1744

Mantri, Y., Davidi, B., Lemaster, J.E., Hariri, A., and Jokerst, J.V. (2020). Iodide-doped precious metal nanoparticles: Measuring oxidative stress: In vivo via photoacoustic imaging. Nanoscale 12. DOI: 10.1039/d0nr03047c

Mantri, Y., and Jokerst, J.V. (2020). Engineering Plasmonic Nanoparticles for Enhanced Photoacoustic Imaging. ACS Nano. DOI: 10.1021/acsnano.0c05215

Moore, C., Wing, R., Pham, T., and Jokerst, J.V. (2020). Multispectral Nanoparticle Tracking Analysis for the Real-Time and Label-Free Characterization of Amyloid-β Self-Assembly in Vitro. Analytical Chemistry 92. DOI: 10.1021/acs.analchem.0c01048

Moore, T.M., Lin, A.J., Strumwasser, A.R., Cory, K., Whitney, K., Ho, T., Ho, T., Lee, J.L., Rucker, D.H., Nguyen, C.Q., et al. (2020). Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice. Frontiers in Physiology 11. DOI: 10.3389/fphys.2020.00690

Moyzis, A.G., Lally, N.S., Liang, W., Leon, L.J., Najor, R.H., Orogo, A.M., and Gustafsson, Å.B. (2020). Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise. Journal of Molecular and Cellular Cardiology 146. DOI: 10.1016/j.yjmcc.2020.07.009

Bourgault, R., Matschi, S., Vasquez, M., Qiao, P., Sonntag, A., Charlebois, C., Mohammadi, M., Scanlon, M.J., Smith, L.G., and Molina, I. (2020). Constructing functional cuticles: Analysis of relationships between cuticle lipid composition, ultrastructure and water barrier function in developing adult maize leaves. Annals of Botany 125. DOI: 10.1093/aob/mcz143

Nandi, S.S., Katsurada, K., Sharma, N.M., Anderson, D.R., Mahata, S.K., and Patel, K.P. (2020). Mmp9 inhibition increases autophagic flux in chronic heart failure. American Journal of Physiology - Heart and Circulatory Physiology 319. DOI: 10.1152/AJPHEART.00032.2020

Padhan, D.K., Sengupta, A., Patra, M., Ganguly, A., Mahata, S.K., and Sen, M. (2020). CCN6 regulates mitochondrial respiratory complex assembly and activity. FASEB Journal 34. DOI: 10.1096/fj.202000405RR

Park, J., Chariou, P.L., and Steinmetz, N.F. (2020). Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles. Bioconjugate Chemistry 31. DOI: 10.1021/acs.bioconjchem.0c00118

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Hu, H., and Steinmetz, N.F. (2020). Doxorubicin-Loaded Physalis Mottle Virus Particles Function as a pH-Responsive Prodrug Enabling Cancer Therapy. Biotechnology Journal 15. DOI: 10.1002/biot.202000077

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2019

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Chang, Y.J., Li, Y.S., Wu, C.C., Wang, K.C., Huang, T.C., Chen, Z., and Chien, S. (2019). Extracellular MicroRNA-92a Mediates Endothelial Cell-Macrophage Communication. Arteriosclerosis, Thrombosis, and Vascular Biology 39. DOI: 10.1161/ATVBAHA.119.312707

Chariou, P.L., Wang, L., Desai, C., Park, J., Robbins, L.K., von Recum, H.A., Ghiladi, R.A., and Steinmetz, N.F. (2019). Let There Be Light: Targeted Photodynamic Therapy Using High Aspect Ratio Plant Viral Nanoparticles. Macromolecular Bioscience 19. DOI: 10.1002/mabi.201800407

Chen, F., Zhao, E.R., Hu, T., Shi, Y., Sirbuly, D.J., and Jokerst, J.V. (2019). Silicon carbide nanoparticles as a photoacoustic and photoluminescent dual-imaging contrast agent for long-term cell tracking. Nanoscale Advances 1. DOI: 10.1039/c9na00237e

Chen, F., Zhao, E.R., Hableel, G., Hu, T., Kim, T., Li, J., Gonzalez-Pech, N.I., Cheng, D.J., Lemaster, J.E., Xie, Y., et al. (2019). Increasing the Efficacy of Stem Cell Therapy via Triple-Function Inorganic Nanoparticles. ACS Nano. DOI: 10.1021/acsnano.9b00653

Duran, P., Ward, S., Christman, K.L., and Alperin, M. (2019). Mechanical impact of parturition-related strains on rat pelvic striated sphincters. Neurourology and Urodynamics 38. DOI: 10.1002/nau.23946

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Kim, B., Sun, S., Varner, J.A., Howell, S.B., Ruoslahti, E., and Sailor, M.J. (2019). Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA. Advanced Materials 31. DOI: 10.1002/adma.201902952

Koffler, J., Zhu, W., Qu, X., Platoshyn, O., Dulin, J.N., Brock, J., Graham, L., Lu, P., Sakamoto, J., Marsala, M., et al. (2019). Biomimetic 3D-printed scaffolds for spinal cord injury repair. Nature Medicine 25. DOI: 10.1038/s41591-018-0296-z

Lemaster, J.E., Jeevarathinam, A.S., Kumar, A., Chandrasekar, B., Chen, F., and Jokerst, J.V. (2019). Synthesis of Ultrasmall Synthetic Melanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions. ACS Applied Bio Materials 2. DOI: 10.1021/acsabm.9b00747

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2018

López-Erauskin, J., Tadokoro, T., Baughn, M.W., Myers, B., McAlonis-Downes, M., Chillon-Marinas, C., Asiaban, J.N., Artates, J., Bui, A.T., Vetto, A.P., et al. (2018). ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron 100. DOI: 10.1016/j.neuron.2018.09.044

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Sarkar, A., Mei, A., Paquola, A.C.M., Stern, S., Bardy, C., Klug, J.R., Kim, S., Neshat, N., Kim, H.J., Ku, M., et al. (2018). Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell 22. DOI: 10.1016/j.stem.2018.04.009

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2017

Shentu, T.P., Huang, T.S., Cernelc-Kohan, M., Chan, J., Wong, S.S., Espinoza, C.R., Tan, C., Gramaglia, I., Van Der Heyde, H., Chien, S., and Hagood, J.S. (2017). Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation. Scientific Reports 7. DOI: 10.1038/s41598-017-18288-9

Syed, G.H., Khan, M., Yang, S., and Siddiqui, A. (2017). Hepatitis C Virus Lipoviroparticles Assemble in the Endoplasmic Reticulum (ER) and Bud off from the ER to the Golgi Compartment in COPII Vesicles. Journal of Virology 91. DOI: 10.1128/jvi.00499-17

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Chapelin, F., Gao, S., Okada, H., Weber, T.G., Messer, K., and Ahrens, E.T. (2017). Fluorine-19 nuclear magnetic resonance of chimeric antigen receptor T cell biodistribution in murine cancer model. Scientific Reports 7. DOI: 10.1038/s41598-017-17669-4

Ditsworth, D., Maldonado, M., McAlonis-Downes, M., Sun, S., Seelman, A., Drenner, K., Arnold, E., Ling, S.C., Pizzo, D., Ravits, J., et al. (2017). Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathologica 133. DOI: 10.1007/s00401-017-1698-6

Döhrmann, S., Larock, C.N., Anderson, E.L., Cole, J.N., Ryali, B., Stewart, C., Nonejuie, P., Pogliano, J., Corriden, R., Ghosh, P., and Nizet, V. (2017). Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones. Scientific Reports 7. DOI: 10.1038/srep43039

Eguchi, A., Lazaro, R.G., Wang, J., Kim, J., Povero, D., Willliams, B., Ho, S.B., Stärkel, P., Schnabl, B., Ohno-Machado, L., et al. (2017). Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology 65. DOI: 10.1002/hep.28838

Fujita, N., Huang, W., Lin, T.H., Groulx, J.F., Jean, S., Nguyen, J., Kuchitsu, Y., Koyama-Honda, I., Mizushima, N., Fukuda, M., and Kiger, A.A. (2017). Genetic screen in drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. eLife 6. DOI: 10.7554/eLife.23367

Guimarães-Camboa, N., Cattaneo, P., Sun, Y., Moore-Morris, T., Gu, Y., Dalton, N.D., Rockenstein, E., Masliah, E., Peterson, K.L., Stallcup, W.B., et al. (2017). Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell 20. DOI: 10.1016/j.stem.2016.12.006

Herai, R.H., Negraes, P.D., and Muotri, A.R. (2017). Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA. Human Molecular Genetics 26. DOI: 10.1093/hmg/ddx142

Huang, W., Zaheri, A., Jung, J.Y., Espinosa, H.D., and McKittrick, J. (2017). Hierarchical structure and compressive deformation mechanisms of bighorn sheep (Ovis canadensis) horn. Acta Biomaterialia 64. DOI: 10.1016/j.actbio.2017.09.043

Huang, Y., Li, Y., Hu, Z., Yue, X., Proetto, M.T., Jones, Y., and Gianneschi, N.C. (2017). Mimicking Melanosomes: Polydopamine Nanoparticles as Artificial Microparasols. ACS Central Science 3. DOI: 10.1021/acscentsci.6b00230

Kojima, M., Gimenes-Junior, J.A., Langness, S., Morishita, K., Lavoie-Gagne, O., Eliceiri, B., Costantini, T.W., and Coimbra, R. (2017). Exosomes, not protein or lipids, in mesenteric lymph activate inflammation. Journal of Trauma and Acute Care Surgery 82. DOI: 10.1097/ta.0000000000001296

2016

Aznar, N., Patel, A., Rohena, C.C., Dunkel, Y., Joosen, L.P., Taupin, V., Kufareva, I., Farquhar, M.G., and Ghosh, P. (2016). AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin. eLife 5. DOI: 10.7554/eLife.20795

2015

Wang, H., Misaki, T., Taupin, V., Eguchi, A., Ghosh, P., and Farquhar, M.G. (2015). GIV/Girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin. Journal of the American Society of Nephrology 26. DOI: 10.1681/ASN.2013090985

Lo, I.C., Gupta, V., Midde, K.K., Taupin, V., Lopez-Sanchez, I., Kufareva, I., Abagyan, R., Randazzo, P.A., Farquhar, M.G., and Ghosh, P. (2015). Activation of Gαi at the Golgi by GIV/Girdin Imposes Finiteness in Arf1 Signaling. Developmental Cell 33. DOI: 10.1016/j.devcel.2015.02.009

2014

Neumann, A., Berends, E.T.M., Nerlich, A., Molhoek, E.M., Gallo, R.L., Meerloo, T., Nizet, V., Naim, H.Y., and Von Köckritz-Blickwede, M. (2014). The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps. Biochemical Journal 464. DOI: 10.1042/BJ20140778

2013

Shah, M., Baterina, O.Y., Taupin, V., and Farquhar, M.G. (2013). ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression. Journal of Cell Biology 202. DOI: 10.1083/jcb.201211110

2012

Varsano, T., Taupin, V., Guo, L., Baterina, O.Y., and Farquhar, M.G. (2012). The PDZ Protein GIPC Regulates Trafficking of the LPA1 Receptor from APPL Signaling Endosomes and Attenuates the Cell's Response to LPA. PLoS ONE 7. DOI: 10.1371/journal.pone.0049227

Dores, M.R., Chen, B., Lin, H., Soh, U.J.K., Paing, M.M., Montagne, W.A., Meerloo, T., and Trejo, J.A. (2012). ALIX binds a YPX 3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. Journal of Cell Biology 197. DOI: 10.1083/jcb.201110031

Beas, A.O., Taupin, V., Teodorof, C., Nguyen, L.T., Garcia-Marcos, M., and Farquhar, M.G. (2012). Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin). Molecular Biology of the Cell 23. DOI: 10.1091/mbc.E12-02-0133

2009

Yamasaki, A., Menon, S., Yu, S., Barrowman, J., Meerloo, T., Oorschot, V., Klumperman, J., Satoh, A., and Ferro-Novick, S. (2009). mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles. Molecular Biology of the Cell 20. DOI: 10.1091/mbc.E09-05-0387

Dippold, H.C., Ng, M.M., Farber-Katz, S.E., Lee, S.K., Kerr, M.L., Peterman, M.C., Sim, R., Wiharto, P.A., Galbraith, K.A., Madhavarapu, S., et al. (2009). GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding. Cell 139. DOI: 10.1016/j.cell.2009.07.052

2008

Federovitch, C.M., Jones, Y.Z., Tong, A.H., Boone, C., Prinz, W.A., and Hampton, R.Y. (2008). Genetic and Structural Analysis of Hmg2p-induced Endoplasmic Reticulum Remodeling in Saccharomyces cerevisiae. Molecular Biology of the Cell 19. DOI: 10.1091/mbc.e07-11-1188

2004

Zheng, B., Lavoie, C., Tang, T.D., Ma, P., Meerloo, T., Beas, A., and Farquhar, M.G. (2004). Regulation of epidermal growth factor receptor degradation by heterotrimeric Gαs protein. Molecular Biology of the Cell 15. DOI: 10.1091/mbc.E04-06-0446

2003

Nagai, M., Meerloo, T., Takeda, T., and Farquhar, M.G. (2003). The Adaptor Protein ARH Escorts Megalin to and through Endosomes. Molecular Biology of the Cell 14. DOI: 10.1091/mbc.E03-06-0385

Fischer, T., De Vries, L., Meerloo, T., and Farquhar, M.G. (2003). Promotion of Gαi3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. Proceedings of the National Academy of Sciences of the United States of America 100. DOI: 10.1073/pnas.1432965100

2002

Zhong, Q., Lazar, C.S., Tronchère, H., Sato, T., Meerloo, T., Yeo, M., Songyang, Z., Emr, S.D., and Gill, G.N. (2002). Endosomol localization and function of sorting nexin 1. Proceedings of the National Academy of Sciences of the United States of America 99. DOI: 10.1073/pnas.092142699

Babst, M., Katzmann, D.J., Estepa-Sabal, E.J., Meerloo, T., and Emr, S.D. (2002). ESCRT-III: An endosome-associated heterooligomeric protein complex required for MVB sorting. Developmental Cell 3. DOI: 10.1016/S1534-5807(02)00220-4

Lavoie, C., Meerloo, T., Lin, P., and Farquhar, M.G. (2002). Calnuc, an EF-hand Ca2+-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells. Molecular Endocrinology 16. DOI: 10.1210/me.2002-0079

2001

Molero, J.C., Whitehead, J.P., Meerloo, T., and James, D.E. (2001). Nocodazole Inhibits Insulin-stimulated Glucose Transport in 3T3-L1 Adipocytes via a Microtubule-independent Mechanism. Journal of Biological Chemistry 276. DOI: 10.1074/jbc.M105452200

2000

Martin, S., Ramm, G., Lyttle, C.T., Meerloo, T., Stoorvogel, W., and James, D.E. (2000). Biogenesis of insulin-responsive GLUT4 vesicles is independent of brefeldin A-sensitive trafficking. Traffic 1. DOI: 10.1034/j.1600-0854.2000.010809.x

Millar, C.A., Meerloo, T., Martin, S., Hickson, G.R.X., Shimwell, N.J., Wakelam, M.J.O., James, D.E., and Gould, G.W. (2000). Adipsin and the glucose transporter GLUT4 traffic to the cell surface via independent pathways in adipocytes. Traffic 1. DOI: 10.1034/j.1600-0854.2000.010206.x